Friday, April 28, 2017

F18 Alzheimer's Scan Delivers Better Prescriptions & Fewer Tests

Caregivers, and healthcare professionals,here is some great information

Here is a great 
dementia resource for caregivers and healthcare professionals,

Your residents will love the Amazon Kindle Fire

Here is information on being the best 
caregiver you can be


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The Dementia Caregiver's Little Book of Hope [Kindle Edition


Today's state-of-the-art in diagnosing Alzheimer's is the F18 PET Scan. See how it changed one man's life. Learn how 87% of patients who received an F18 scan made at least one change in their treatment plan.




Until recently, the hardest part in diagnosing Alzheimer's was the difficulty in "seeing" what was going on in the brain. F18 PET scans changed all that, allowing doctors to "see" how much Alzheimer's plaque, if any, appeared in the brain. 

When the first F18 tests hit the market, they cost a few thousand dollars and were available from only one source. Since then, there has been a rush of activity on the part of pharmaceutical companies to bring better and less expensive F18 tests to market.

The first F18 test to detect brain amyloid deposits (also known as Alzheimer's plaques) was approved by the FDA in 2012. It was called Florbetapir F18 (renamed AMYViD™).

F18 tests approved by the FDA include:
Generic NameBrand Name
Flutemetamol F18Vizamyl™
Florbetaben F18Neuraceq™
Florbetapir F18AMYViD™

A Closer Look at Florbetapir F18

Seeing the amount of Alzheimer's plaque provides doctors with useful information on treatment and further testing for patients with cognitive impairment, according to the study published online by the journal Alzheimer Disease & Associated Disorders. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

Positron emission tomography (PET) scans "light up" the florbetapir F18 biomarker to show amyloid plaques in the brain — a characteristic feature of Alzheimer's disease (AD).

"Amyloid imaging results altered physicians' diagnostic thinking, intended testing and management of patients undergoing evaluation for cognitive decline," according to the study by Dr. Mark Mintun of Avid Pharmaceuticals, Philadelphia, and colleagues.

Is It Alzheimer's? Florbetapir Provides Evidence

The researchers designed a "real-world" study to determine how florbetapir would affect clinical management of patients with cognitive impairment. While a florbetapir PET scan showing amyloid plaques doesn't prove that AD is present, it provides a previously unavailable piece of evidence to support the diagnosis.

The study included 229 patients seen by neurologists or other specialists for evaluation of cognitive decline or impairment of uncertain etiology. Before the florbetapir PET scan, doctors provided a provisional diagnosis, an estimate of their diagnostic confidence, and their plans for further testing and treatment. The goal was to assess the value of florbetapir PET in making the final diagnosis and in providing doctors with useful information for clinical decision making.

The florbetapir PET scans showed amyloid deposits in 113 out of 229 patients. The information provided led doctors to change their diagnosis in 55 percent of cases.

When the provisional diagnosis was AD, imaging results led to a change in diagnosis in 37 percent of cases. When the pre-scan diagnosis was either “indeterminate” or another cause of dementia, the diagnosis changed in over 60 percent of cases. In either direction, the scans increased the physicians' ratings of diagnostic confidence by about 20 percent.

Impact on Treatment and Testing Decisions

Florbetapir PET also provided useful information for treatment decision-making: in 87 percent of patients, the results contributed to at least one change in the treatment plan. The main impact was in deciding whether or not to use medications that are helpful in AD. The scan results also affected decisions on further testing—in many cases, physicians dropped plans to perform additional brain imaging studies or neuropsychological tests.

Alzheimer disease is the most common cause of dementia, but the diagnosis can be challenging to make. The only definitive way to diagnose AD is by autopsy examination of the brain after death. Up to 20 percent of patients diagnosed with AD turn out not to have had AD on autopsy, while up to 40 percent of patients diagnosed with other causes of dementia have evidence of AD at autopsy.

Florbetapir PET is the first FDA-approved imaging that can estimate amyloid deposits in the brain of a living patient. Previous studies have shown that the scans are accurate in identifying patients later shown to have AD at autopsy.

The new results show that florbetapir PET scans can have a significant effect in "real world" clinical evaluation of patients with cognitive impairment. By strengthening the case for or against a diagnosis of AD, this test can have a significant impact on patient management—particularly related to the use of AD medications and the need for further testing. Additional studies will be needed to confirm whether "clinical care that includes amyloid imaging will translate into better outcomes" for patients with cognitive impairment and possible AD.




About Alzheimer Disease & Associated Disorders

Alzheimer Disease & Associated Disorders is a leading international forum for reports of new research findings and new approaches to diagnosis and treatment. Contributions fall within all relevant scientific fields and clinical specialties, including neurobiology, neurochemistry, molecular biology, neurology, neuropathology, neuropsychology, psychiatry, gerontology, and geriatrics.

About Lippincott Williams & Wilkins 

Lippincott Williams & Wilkins (LWW) is a leading international publisher of trusted content delivered in innovative ways to practitioners, professionals and students to learn new skills, stay current on their practice, and make important decisions to improve patient care and clinical outcomes. LWW is part of Wolters Kluwer Health, a leading global provider of information, business intelligence and point-of-care solutions for the healthcare industry. Wolters Kluwer Health is part of Wolters Kluwer, a market-leading global information services company with 2011 annual revenues of €3.4 billion ($4.7 billion).

Comment or Share:

  1. The ARTICLES :
    1) In the article published online in October 16,2013 , in the prestigeous medical journal called Neurology , that is the official journal of the American Academy of Neurology , with the title “Pulse wave velocity is associated with β- amyloid deposition in the brains of very elderly adults” - authors Timothy M. Hughes, PhD, Steven T. DeKosky, MD and colleagues , studied a cohort of 91 DEMENTIA-FREE participants aged 83–96 years.In 2009, participants completed brain MRI and PET imaging using Pittsburgh compound B (PiB).
    In October 17 , 2013 , one of the the authors of the article , M.Hughes,PhD , in an interview in the site Medpage Today , declared :"When we began looking at the brains of (COGNITIVELY NORMAL) older adults we saw a lot MORE AMYLOID than we expected to see," Hughes continued to MedPage Today "That led to the REALIZATION that the ACCUMULATION of amyloid in the brain may be COMMON IN AGING, and NOT as tied to Alzheimer's disease as we have thought."
    2) In another article published online in April 17,2013 inthe american medical journal called Annals of Neurology , that is the official journal of the American Neurological Association , with the title “In vivo assessment of amyloid-β deposition in nondemented very elderly subjects.” the authors wrote :
    "Made a study that analysed the betamyloid deposition in one hundred ninety NONDEMENTED subjects aged ≥82 years old , to determine the proportion of Aβ-positive scans” they found that
    “ A high proportion of the cognitively normal subjects , fifty one percent (51%) were PiB-positive.
    "And the authors wrote too that : “The data revealed a 55% prevalence of PiB positivity in NONDEMENTED subjects age >80 years”.
    Amyloid tracers as florbetapir can leads 55% of patients that do it test , to be misdiagnosed as having AD, WHILE THEY ARE HEALTHY PATIENTS, that only have the betamyloid accumulation that is age-related but that do NOT cause dementias.
    Reply
  2. We can conclude that we can use two definitions as the main arguments about why the “amyloid hypothesis” is a flawed hypothesis or a sophism, and that the misconception of the amyloid hypothesis leads to the misdiagnosis using amyloid tracers.
    As is well know , the definition of a scientific premise is :
    "A statement that an argument claims will induce or justify a conclusion ."
    Or in other words :
    A scientific premise is an assumption that something is true”.

    But the definition of a scientific sophism is :
    " When a so called “premise” can NOT be supported by solids scientifics foundations or proofs , then that is considered a "false premise” , so called a sophism ( a fallacious argumentation – or a False premise).

    We can use the definition of a scientific premise pasted above to "open our minds" , to see that based in the scientific articles that I pasted parts of the texts before , and using the logical reasoning we can see that betamyloid accumulation it is NOT the cause of AD , and it is NOT the main culprit of AD symtpons .
    Then to use amyloid tracers as a reference to try to do a diagnosis , or to treat based in the false premise of the amyloid hupothesis ,is an absolute and very expensive nonsense.
    Reply

    Replies


    1. Mr. Oliveira, please make your point in under 200 words. Your posts are full of good information, but their heavy length makes them unlikely to be read as a comment.

      Regarding your argument that F18 tests are nonsense, please be a little more humble. Give the massive number of researchers and doctors using F18 tests a little more credit.

      F18 is NOT used to test for plaque to prove that a person HAS Alzheimer's. It tests for plaque because if there is very little plaque, then a doctor can be confident that a person's dementia is NOT CAUSED by Alzheimer's.

      Your entire argument is based on the fact that a person may have plaque and may not have Alzheimer's. While that may be true, it has nothing to do with what F18 tests do. In the video above, the person thought he had Alzheimer's. Thanks to the F18 test, he is relieved to know he does not and can now look for better therapy & treatment. (167 WORDS :) )
    2. Thank you Alz week.
      But to proof the point that amyloid tracers do not makes sense to the majority of dementia patients with AD , only putting all the information above, to the readers have the chance to do theirs own research based in the articles above, and to readers use theirs own logic to think about it.
      Thank you very much
      Carlos (in sixty four words)
  3. I appreciate both your civility (getting rare these days) and your information
    Reply
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Tuesday, April 25, 2017

Funding for Alzheimer's

Caregivers, and healthcare professionals,here is some great information

Here is a great 
dementia resource for caregivers and healthcare professionals,

Your residents will love the Amazon Kindle Fire

Here is information on being the best 
caregiver you can be


Here is a way for nurses administrators, social workers and other health care  professionals to get an easyceu or two

Follow 
alzheimersideas on twitter


The Dementia Caregiver's Little Book of Hope [Kindle Edition

Dear Reader
We have an important ACTION ALERT for you TO HELP IN THE FIGHT AGAINST ALZHEIMER’S.
The Massachusetts State House of Representatives is beginning their state budget debate Monday, April 24th. Representative Danielle Gregoire (Marlborough) has filed an amendment to dedicate $250,000 for a Alzheimer’s public awareness and education campaign.  It is Amendment #124. 
Please use the link provided to email your own State Representative and ask them to pass AMENDMENT #124.  It is easy and simple and only takes a minute. Thank you for all that you do. 
Please act NOW and Click Here!
Thank you,
Daniel C. Zotos, Director of Public Policy & Advocacy 


Saturday, April 22, 2017

Treating dementia with marijuana

Caregivers, and healthcare professionals,here is some great information

Here is a great 
dementia resource for caregivers and healthcare professionals,

Your residents will love the Amazon Kindle Fire

Here is information on being the best 
caregiver you can be


Here is a way for nurses administrators, social workers and other health care  professionals to get an easyceu or two

Follow 
alzheimersideas on twitter




The Dementia Caregiver's Little Book of Hope [Kindle Edition

Sundownerfacts

As the number of states legalizing medical marijuana/cannabis are increasing across the United States, many families and caregivers of individuals with cognitive decline are beginning to ask if the herbal supplement may be a good option for their loved one. With the availability of safe, legal cannabis, an increasing number of individuals are finding that treating dementia with cannabis may be a viable option.

A brief history of medical cannabis use

Cannabis has been used for medicinal purposes for well over 5000 years, and it was not until 1941, in response to articles that have since been proven false published in the late 20’s, that it was removed from the US pharmacopia. In recent years, many western countries have begun limited medical marijuana allowances, with a strongly positive response from patients and indications that the drug is primarily being used among patients to successfully treat the various physical and mental challenges it was prescribed to address.

What symptoms medical marijuana may alleviate

Use of certain strains of medical cannabis has been demonstrated anecdotally and scientifically to alleviate various symptoms of aging, including symptoms prominent for a loved one with sundowners. It is effective in treating insomnia, and calming down anxiety. It also has strong effects of calming down problematic behaviors, including panic driven flight responses or violence. Marijuana also has a potent pain relieving effect, and if your loved one is nearing the end of their lives may be a gentle way to help them stay calm and comfortable in their final weeks or months.

Will it harm my loved ones memory?

Given the long association with marijuana and memory problems, it is natural that someone who is already helping a loved one through cognitive decline would be worried about potential side effects that may worsen the condition. While it’s true that cannabis may induce some short-term memory loss (namely, an individual may not be able to clearly remember things moment to moment while the marijuana is active in their system), it has only demonstrated long term memory loss effects with chronic use over several years, or use early in brain development. Promising studies have also demonstrated that THC, the active compound in marijuana, may in fact delay the formation of brain clogging Alzheimers plaque better than pharmaceuticals currently available on the market.

How to find safe, legal medical marijuana

First, find out whether or not your state has medical marijuana laws in effect. If your state does support medical marijuana, your public health department or basic internet searching should help you find the process for gaining access to dispensaries, which varies state to state. You may need to see one or several doctors to confirm a diagnoses for the prescription. These specialists will also help determine which strain or hybrid is best for your loved ones specific situation, as different types of marijuana are bred to amplify different therapeutic effects. Once you have the prescription, you will go to a dispensary, where pharmacy grade, medically regulated marijuana is sold. There will be a variety of options to choose from, including herbs for smoking, oils, resins, different kinds of smoking apparatus, and edible goods such as candies, cookies, or butter. You may need to experiment a little bit to find out what works best for your loved one: smoked cannabis tends to act faster and stronger, whereas ingested tends to last longer and take a while to set in. Depending on what symptoms it is being used to treat, and your loved ones feelings about the various options, it may take some experimentation before you find what works for you.

Treating dementia with cannabis – your story.

An increasing number of families of individuals experiencing cognitive decline are coming forward and sharing their stories on the Internet, for other caregivers to gain hope and advice from. In one inspirational story from Skunk Pharm Research LLC, introduction of medical marijuana to a mother who had become increasingly violent and aggressive as her Alzheimers worsened brought a woman comfort and peace in her last years of life, and reunited a family. You can read their moving story here. We would like to extend an invitation to you, our readers, to share your own stories, if you have one to share. By collecting stories and hosting them on our site (with your permission, and anonymously if requested), you can help educate and inspire families like your own. If you have a story concerning the use of medical cannabis in the treatment of sundowner syndrome or dementia, please share it with our readers below.

Updates March 2017

California’s Senior Medical Cannabis Market is definitely leading the way in the US. Here is a chart from the team of David Downs and John Blanchard at The Chronicle. For more great information on the topic of cannabis use and the aging see the Green State: Seniors’ guide to Cannabis.
Chart of Marijuana Use by Seniors


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