GEN News Highlights
A group of investigators report that it is possible to enhance insulin-degrading enzyme’s (IDE) ability to destroy amyloid beta (A-beta) with synthetic small molecules. In laboratory experiments, they found that one agent, dubbed Ia1, increased the activity of IDE by about 700%, while the second compound, Ia2, increased it by almost 400%.
The research, which is published in the April 22 online issue of PLoS ONE, was a collaboration between Mayo Clinic Florida, The Scripps Research Institute, and Harvard Medical School. The study is called “Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening.”
IDE was the first degrading enzyme implicated in the imbalance seen between the production and elimination of A-beta in the brains of Alzheimer’s patients, according to lead researcher, Malcolm Leissring, Ph.D., from Mayo's department of neuroscience. “We don't know why that balance is skewed in individuals that develop Alzheimer's disease, but one hypothesis is that as we age, activity of the enzymes that destroy A-beta goes down.”
The scientists thus screened tens of thousands of chemicals looking for ones that could bind to IDE and modulate its activity. That led to discovery and testing of Ia1 and Ia2. Dr. Leissring says that the success they achieved in their test tube experiments offers a new path for more advanced research.
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Past Alzheimer’s Research
Researchers Develop Standard of Testing for.........read the whole article
For a great resource for those with dementia, caregivers and healthcare professinals, click here
For information on being the best caregiver you can be, click here
For more interesting dementia articles and activities, click here
Sunday, May 10, 2009
Friday, May 8, 2009
Preventing "brain aging"
Geriatric neurologist and author tackles what he calls the myths of Alzheimer's.
By SARAH MORAN Special to the Star Tribune
Alzheimer's disease is a 100-year-old myth that's over the hill. So says Dr. Peter Whitehouse, a geriatric neurologist and author of "The Myth of Alzheimer's: What You Aren't Being Told About Today's Most Dreaded Diagnosis."
Whitehouse, who played an important role in brain research that led to the first four medications designed to treat Alzheimer's, has replaced the term "Alzheimer's disease" with "severe brain aging." That distinction, he says, makes all the difference. He says we need to stop throwing money at searching for a cure to what he calls "age-associated cognitive challenges." Instead of medication, the focus should be on preventing brain aging through simple strategies such as exercise, reading and eating right, he says.
We talked with Whitehouse ahead of his visit to the Twin Cities this week.
Q What myths do you want to dispel?
.......read the whole article
For a great resource for those with dementia, caregivers and healthcare professinals, click here
For information on being the best caregiver you can be, click here
For more interesting dementia articles and activities, click here
By SARAH MORAN Special to the Star Tribune
Alzheimer's disease is a 100-year-old myth that's over the hill. So says Dr. Peter Whitehouse, a geriatric neurologist and author of "The Myth of Alzheimer's: What You Aren't Being Told About Today's Most Dreaded Diagnosis."
Whitehouse, who played an important role in brain research that led to the first four medications designed to treat Alzheimer's, has replaced the term "Alzheimer's disease" with "severe brain aging." That distinction, he says, makes all the difference. He says we need to stop throwing money at searching for a cure to what he calls "age-associated cognitive challenges." Instead of medication, the focus should be on preventing brain aging through simple strategies such as exercise, reading and eating right, he says.
We talked with Whitehouse ahead of his visit to the Twin Cities this week.
Q What myths do you want to dispel?
.......read the whole article
For a great resource for those with dementia, caregivers and healthcare professinals, click here
For information on being the best caregiver you can be, click here
For more interesting dementia articles and activities, click here
Wednesday, May 6, 2009
Do you need apple iphone accessories?
If you are a caregiver of a person with dementia, you need a gadget that is easy to use and stores a lot of information for you.
You need the apple iphone and necessary accessories.
I ran across this website, MobileFun.co.uk. It offers terrific
iphone accessories
For example, you can get InvisibleSHIELD Full Body Protector. This is needed because when you are living a person with dementia, He or she can take your things and put them in the most peculiar places.
Even if you try to hide your iphone, a loved one with dementia could find it. You want to protect your apple iphone with the best protection possible. The InvisibleSHIELD Full Body Protector is just what you need and MobileFun.co.uk is the place to get it.
The shield prevents scratches and actually makes the phone easier to use in my opinion.
Another of the apple iphone accessories you can get from MobileFun.co.uk is the Mercury Desk Stand. This stand is great because you have access to all the features of the phone while having it on a strong sturdy stand. It also has rubber feet so your desk or table will not get scratched. A side benefit is that it is pleasing to look at. Of course, MobileFun.co.uk has a great deal on this accessory.
In addition to the two accassories mentioned above, another of the iphone accessories is the
WildCharge Universal Wireless Charger & iPhone 3G Adapter. This item is actually not in stock yet. However this item is sure to be on the must have list. Of the apple iphone accessories this is going to be the most asked for. You will be able to get it at MobileFun.co.uk soon
If you do not want to go that high tech,you can get Apple iPhone 3G USB Sync & Charge Cradle. It is currently in stock and is not as costly.
You do not have to make up your mind right away. I know living with a person who has dementia is most challanging. You have one less thing to worry about though if you buy apple iphones and accexssories from MobileFun.co.uk
You need the apple iphone and necessary accessories.
I ran across this website, MobileFun.co.uk. It offers terrific
iphone accessories
For example, you can get InvisibleSHIELD Full Body Protector. This is needed because when you are living a person with dementia, He or she can take your things and put them in the most peculiar places.
Even if you try to hide your iphone, a loved one with dementia could find it. You want to protect your apple iphone with the best protection possible. The InvisibleSHIELD Full Body Protector is just what you need and MobileFun.co.uk is the place to get it.
The shield prevents scratches and actually makes the phone easier to use in my opinion.
Another of the apple iphone accessories you can get from MobileFun.co.uk is the Mercury Desk Stand. This stand is great because you have access to all the features of the phone while having it on a strong sturdy stand. It also has rubber feet so your desk or table will not get scratched. A side benefit is that it is pleasing to look at. Of course, MobileFun.co.uk has a great deal on this accessory.
In addition to the two accassories mentioned above, another of the iphone accessories is the
WildCharge Universal Wireless Charger & iPhone 3G Adapter. This item is actually not in stock yet. However this item is sure to be on the must have list. Of the apple iphone accessories this is going to be the most asked for. You will be able to get it at MobileFun.co.uk soon
If you do not want to go that high tech,you can get Apple iPhone 3G USB Sync & Charge Cradle. It is currently in stock and is not as costly.
You do not have to make up your mind right away. I know living with a person who has dementia is most challanging. You have one less thing to worry about though if you buy apple iphones and accexssories from MobileFun.co.uk
Monday, May 4, 2009
Making the move because of dementia
Sooner or later you, as a caregiver, will be faced with the task of moving someone with dementia. Whether you are moving his or her belongings into your home, into an assisted living facility or nursing home or a combination, the job will be most difficult.
You cannot rely on the help of a person with dementia because he or she will be unable to focus on the task. In fact he or she may fight you on the idea of moving.
Thus you will need a company that can do it all for you. I came across such a company in the United Kingdom. It is called Moveme.com.
Just as the name suggests, this company helps you with all aspects of the moving process. Of course. they will give you a free quote
What do these people do?
First they can plan and organize your move. This is key because you need someone who can organize things for you when you yourself have so much on your mind.
They can get localremoval quotes
This can be a headache, but these guys make it easy
They can also transfer the uilities if that is necessary.
There can also compare the prices of home services if this is something you need
What is really great is that they can find aman and van for you if you need a vehicle and a person to help move belongings
Do you have a moving company that was recommended to you? Do you want to see if they have the best deals? Well moveme.com can check out a moving company for you
They have the ability to investigate multiple moving companies for you as well
So if you need a removal company or want to have the chance to have many removal companies at your disposal, go to moveme.com
Remember before they do anything, you can get reliable removal quotes
So if you need a removal company or want to have a number of removal companies quotes available to you, moveme.com can get the job done.
Yes moveme.com can help you move a loved one with dementia with relative ease. There will be no guess work on your part. Make a hard job easier and contact moveme.com
You cannot rely on the help of a person with dementia because he or she will be unable to focus on the task. In fact he or she may fight you on the idea of moving.
Thus you will need a company that can do it all for you. I came across such a company in the United Kingdom. It is called Moveme.com.
Just as the name suggests, this company helps you with all aspects of the moving process. Of course. they will give you a free quote
What do these people do?
First they can plan and organize your move. This is key because you need someone who can organize things for you when you yourself have so much on your mind.
They can get localremoval quotes
This can be a headache, but these guys make it easy
They can also transfer the uilities if that is necessary.
There can also compare the prices of home services if this is something you need
What is really great is that they can find aman and van for you if you need a vehicle and a person to help move belongings
Do you have a moving company that was recommended to you? Do you want to see if they have the best deals? Well moveme.com can check out a moving company for you
They have the ability to investigate multiple moving companies for you as well
So if you need a removal company or want to have the chance to have many removal companies at your disposal, go to moveme.com
Remember before they do anything, you can get reliable removal quotes
So if you need a removal company or want to have a number of removal companies quotes available to you, moveme.com can get the job done.
Yes moveme.com can help you move a loved one with dementia with relative ease. There will be no guess work on your part. Make a hard job easier and contact moveme.com
Hippocampus vulnerable in Alzheimer's
Miami Herald
Q. Why does Alzheimer's disease cause more recent memories to disappear first?
A. According to the National Institute on Aging, www.nia.nih.gov:
Multiple areas of the brain are responsible for memory-associated functions such as processing information and creating and recalling memories. Deep within the brain, new memories are formed and stored in the hippocampus and associated structures. Then, in a process called consolidation, memories are stored for the long-term throughout the cortex, the outermost layer of the brain.
"Recent memory is affected first in AD because the hippocampus and nearby entorhinal cortex are the first brain areas damaged by the disease. As a result, a person with AD may remember every detail of a childhood event but be unable to recall something that happened yesterday or an hour ago. This pattern of damage also can lead to confusion about the past and present. A person may think a long-deceased relative is still alive, for example, because.....read the whole article
For a great resource for those with dementia, caregivers and healthcare professinals, click here
For information on being the best caregiver you can be, click here
For more interesting dementia articles and activities, click here
Q. Why does Alzheimer's disease cause more recent memories to disappear first?
A. According to the National Institute on Aging, www.nia.nih.gov:
Multiple areas of the brain are responsible for memory-associated functions such as processing information and creating and recalling memories. Deep within the brain, new memories are formed and stored in the hippocampus and associated structures. Then, in a process called consolidation, memories are stored for the long-term throughout the cortex, the outermost layer of the brain.
"Recent memory is affected first in AD because the hippocampus and nearby entorhinal cortex are the first brain areas damaged by the disease. As a result, a person with AD may remember every detail of a childhood event but be unable to recall something that happened yesterday or an hour ago. This pattern of damage also can lead to confusion about the past and present. A person may think a long-deceased relative is still alive, for example, because.....read the whole article
For a great resource for those with dementia, caregivers and healthcare professinals, click here
For information on being the best caregiver you can be, click here
For more interesting dementia articles and activities, click here
Sunday, May 3, 2009
Have you gotten your mother with dementia a gift yet?
Here are some great ideas
Healthnews-stat.com
First on the list of gifts for mom is a book by Susan Berg called Adorable Photographs of Our Baby -- Meaningful, Mind-Stimulating Activities and More for the Memory Challenged, Their Loved Ones and Involved Professionals, This book features baby photographs that seniors with dementia love. This book shares a plethora of idea sand resources for you.
Another gift a dementia mother will fancy is a classic musical video or DVD. Your mother will enjoy watching something from the good old days and singing the songs played throughout the picture.Here are a few suggestions: Singin’ in the Rain, Meet Me in St. Louis, or Shall We Dance
Next is a sing a long CD or audio cassette of their favorite songs. There is a series of these called, Old Time Favorites by Nancy Pitkin
You may want to get a sing a long video where you loved one can see and hear performers singing songs they love. A good one is, Sing-Along with Phil Bernardi: Songs We Know and Love
Here is another idea. Give your mom some...read the whole storyFor a great resource for those with dementia, caregivers and healthcare professinals, click here
For information on being the best caregiver you can be, click here
For more interesting dementia articles and activities, click here
Healthnews-stat.com
First on the list of gifts for mom is a book by Susan Berg called Adorable Photographs of Our Baby -- Meaningful, Mind-Stimulating Activities and More for the Memory Challenged, Their Loved Ones and Involved Professionals, This book features baby photographs that seniors with dementia love. This book shares a plethora of idea sand resources for you.
Another gift a dementia mother will fancy is a classic musical video or DVD. Your mother will enjoy watching something from the good old days and singing the songs played throughout the picture.Here are a few suggestions: Singin’ in the Rain, Meet Me in St. Louis, or Shall We Dance
Next is a sing a long CD or audio cassette of their favorite songs. There is a series of these called, Old Time Favorites by Nancy Pitkin
You may want to get a sing a long video where you loved one can see and hear performers singing songs they love. A good one is, Sing-Along with Phil Bernardi: Songs We Know and Love
Here is another idea. Give your mom some...read the whole storyFor a great resource for those with dementia, caregivers and healthcare professinals, click here
For information on being the best caregiver you can be, click here
For more interesting dementia articles and activities, click here
Friday, May 1, 2009
Ultimate Alzheimer's Rescue Program
Brian Willie
Paying for Alzheimer’s Care can be nearly as devastating as the disease itself, especially now from being sideswiped with dwindling account balances from this recession ... and it's probably one of the last things you want to think about ... but if you can spare a moment I’d like to show you ...
“How Alzheimer’s Families Can Immediately Stop Depleting Assets, Draining Nest Eggs And Finally Gain Back Your Control. ”
24 HOURS AGO … A family battling Alzheimer’s was in a state of panic; worried that they couldn’t afford to adequately care for their loved ones ... but, today, they found help!
If your family is dealing with Alzheimer’s you have more than enough to worry about. Let me help! As the mind and body of your loved one starts to shut down, they will need help-- especially when the need for long-term care is close at hand.
Sadly, the medical symptoms can’t be reversed at this time, BUT THE STRESS AND WORRY OVER THE COSTS, CAN!
We still don’t understand exactly how Alzheimer’s disease damages the brain, but we do know that it strikes gradually and ferociously. And, the financial strain put on families can be just as unkind.
I’m sure you’re more than aware how difficult this disease can be emotionally, physically and financially. It can literally make you feel helpless. The negative impact on your health, employment, income and financial security can cause you to experience high levels of stress and depression.
According to the Alzheimer’s Association, almost 10 million Americans act as Alzheimer’s caregivers, providing some form of care to loved ones with Alzheimer’s or other forms of dementia. Annually, this adds up to a staggering 8.4 billion hours of unpaid care. A contribution valued at $89 billion.
Yet ironically, with billions paid out in government benefits, close to 57% of Americans receive NO FINANCIAL SUPPORT from Medicare, Medicaid or any other government programs.
Financial support that your family is entitled to know about, apply for, and in many cases receive!
I know how hard this wretched disease is to deal with. Like you, I have watched someone special change before my eyes, and I understand how frustrating and overwhelming the disease can be.
I’ve experienced the stress of dealing with someone who seems deliberately difficult or who fails to recognize that something is even wrong…and how a life that was once filled with exuberance has been reduced to the heartache that they may now not recognize you. I know how hard it is to focus on anything else, let alone money.
But, eventually you will have to prepare for your loved one’s long-term care…and the literally shocking costs that you will face.
Find Comfort in Knowing Your
Financial Options
There are many ways to relieve the financial burden that occurs with Alzheimer’s disease. But getting assistance.....read the whole article
For a great resource for those with dementia, caregivers and healthcare professinals, click here
For information on being the best caregiver you can be, click here
For more interesting dementia articles and activities, click here
Paying for Alzheimer’s Care can be nearly as devastating as the disease itself, especially now from being sideswiped with dwindling account balances from this recession ... and it's probably one of the last things you want to think about ... but if you can spare a moment I’d like to show you ...
“How Alzheimer’s Families Can Immediately Stop Depleting Assets, Draining Nest Eggs And Finally Gain Back Your Control. ”
24 HOURS AGO … A family battling Alzheimer’s was in a state of panic; worried that they couldn’t afford to adequately care for their loved ones ... but, today, they found help!
If your family is dealing with Alzheimer’s you have more than enough to worry about. Let me help! As the mind and body of your loved one starts to shut down, they will need help-- especially when the need for long-term care is close at hand.
Sadly, the medical symptoms can’t be reversed at this time, BUT THE STRESS AND WORRY OVER THE COSTS, CAN!
We still don’t understand exactly how Alzheimer’s disease damages the brain, but we do know that it strikes gradually and ferociously. And, the financial strain put on families can be just as unkind.
I’m sure you’re more than aware how difficult this disease can be emotionally, physically and financially. It can literally make you feel helpless. The negative impact on your health, employment, income and financial security can cause you to experience high levels of stress and depression.
According to the Alzheimer’s Association, almost 10 million Americans act as Alzheimer’s caregivers, providing some form of care to loved ones with Alzheimer’s or other forms of dementia. Annually, this adds up to a staggering 8.4 billion hours of unpaid care. A contribution valued at $89 billion.
Yet ironically, with billions paid out in government benefits, close to 57% of Americans receive NO FINANCIAL SUPPORT from Medicare, Medicaid or any other government programs.
Financial support that your family is entitled to know about, apply for, and in many cases receive!
I know how hard this wretched disease is to deal with. Like you, I have watched someone special change before my eyes, and I understand how frustrating and overwhelming the disease can be.
I’ve experienced the stress of dealing with someone who seems deliberately difficult or who fails to recognize that something is even wrong…and how a life that was once filled with exuberance has been reduced to the heartache that they may now not recognize you. I know how hard it is to focus on anything else, let alone money.
But, eventually you will have to prepare for your loved one’s long-term care…and the literally shocking costs that you will face.
Find Comfort in Knowing Your
Financial Options
There are many ways to relieve the financial burden that occurs with Alzheimer’s disease. But getting assistance.....read the whole article
For a great resource for those with dementia, caregivers and healthcare professinals, click here
For information on being the best caregiver you can be, click here
For more interesting dementia articles and activities, click here
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