Want to Live Forever? Antibiotic May Prevent Age-Related Disease in People

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Ever since Spanish explorer Juan Ponce de Leon set out for the New World to find the mythological Fountain of Youth, man has yearned to unlock the mysteries to staying forever young.


Now, 500 years after de Leon’s failed mission (he died in July 1521), medical researchers say an antibiotic pill designed to prevent organ transplant rejection has been shown to help laboratory mice live longer.

The drug, marketed under the brand name Rapamune but known generically as rapamycin or siroliumus, may also someday serve another purpose: Helping extend the lives of people battling age-related disease such as Alzheimer’s disease, cancer, heart disease, and other disorders, researchers said.

“Rapamycin may extend lifespan by postponing death from cancer, by retarding mechanisms of aging, or both,” David Harrison of The Jackson Laboratory in Bar Harbor, Maine and colleagues wrote in their report, published in the journal Nature, according to a Reuters news report.


Lab Rats Live Longer
In laboratory testing, adult female mice given Rapamycin lived 14 percent longer, while male mice given the drug lived nine percent longer lives, the researchers said.

However, people shouldn’t start taking Rapamycin pills daily in an effort to live longer lives, the research team cautioned. For one thing, mice in the experiment were not exposed to any infection, which could have significantly affected the study results. Also, mice do not tend to biologically age the same way as people and tend to live much shorter lives than humans.

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