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Decreased levels of the chemical acetylcholine are seen in patients with Alzheimer's disease. Acetylcholine has an important role in the communication between all cells in the body, including the brain. Some things happen when you have Alzheimer's disease that interfere with brain-cell communication.
Alzheimer's disease is a brain disorder that slowly gets worse over time and cannot be reversed. Alzheimer's disease limits a person's memory and ability to think, reason, learn, make judgments and communicate. According to an article in the "Journal of Molecular Neuroscience" (Volume 17, Number 2, pages 137-145, from October, 2001), accumulation of excess amyloid protein is associated with Alzheimer's disease.
In the early 1900s, acetylcholine (Ach) was the first neurotransmitter to be identified. A neurotransmitter allows communication of information from one nerve cell to another. Acetylcholine is a major neurotransmitter in the brain. It plays an important part in memory, learning and many other brain functions. According to an article in KnowItAlz, an Alzheimer's caregiver community blog, those suffering from Alzheimer's disease have low levels of acetylcholine. The amount of acetylcholine decreases naturally as you age. In Alzheimer's disease, acetylcholine decreases much faster than normal because of the accumulation of two abnormal proteins. These proteins kill acetylcholine-transmitting cells. The gradual death of cholinergic brain cells, cells that transmit acetylcholine, results in a progressive and significant loss of brain function.
One of the leading characteristics of Alzheimer's disease is the buildup ....read all of What Happens to ACH That May Cause Alzheimer's?