Sunday, June 5, 2011

Treatment for Dementia May Be a Cancer Drug

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Reseachers at the University of Texas (UT) Southwestern Medical Center's Alzheimer's and Neurodegenerative Diseases Unit have made a remarkable discovery. The drug Suberoylanilide hydroxamic acid (SAHA) could be
used therapeutically for familial frontotemporal dementia (FTD). There is no treatment for the FTD, a neurological disease as of yet. FTD is the second most common form of non-elderly dementia.

People with FTD are usually diagnosed around the age of 60 though its symptoms may appear much earlier. Its onset is followed by a decline in decision-making ability, behavioral control, and/or language skills. About 25 percent of FTD patients have the familial or inherited form of the disease, in which one copy of the granulin (GRN) gene is normal and one is mutated, thus limiting the reproduction of GRN - a gene that is essential for the survival of nerve cells.

In studies performed by members of the UT Center, UCL A, UCSF, and the University of Massachusetts Medical School , all of Treatment for Dementia May Be a Cancer Drug

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